Aging · 2
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- 12 days ago sciencedirect.com
Senolytic therapy and brain barrier integrity in an animal tauopathy model
A study in animals with tauopathy reports that senolytic therapy preserved the integrity of the blood-brain barrier and promoted microglia homeostasis, an early finding.
- 12 days ago longevity.technology
Targeted partial reprogramming reverses age-related cell signs in animals
A study in animal models tested a precise partial reprogramming method that reversed some age-linked cell changes while keeping cell identity. This is preclinical evidence, still far from proven effects in people.
- 12 days ago news.uq.edu.au
University of Queensland study links master regulator AP-1 to gene shifts in aging
A University of Queensland study analyzed molecular data from people and mice of different ages and found that the regulator AP-1 activates adult-associated genes and lowers early developmental genes across several cell types.
- 12 days ago journals.plos.org
Calorie restriction in mice: longer lifespan, lower resilience
A study published in PLOS ONE, carried out in mice, reports that calorie restriction may extend the animals' lifespan but appears to leave them less resilient. This is an animal result and does not directly show the effect in people.
- 12 days ago genomics.senescence.info
DrugAge database of ageing-related drugs updated
An article announces an update to DrugAge, a database of drugs studied for their effects on ageing. Databases like this help compare compounds already tested, but they do not prove benefit.
- 12 days ago nature.com
How to target senescent cells in the brain: what a Nature review says
A review published in Nature Reviews Drug Discovery gathers research on senescent cells in the central nervous system, including drugs in development that aim to remove them or modulate their effect on nearby tissue.
- 12 days ago nature.com
IL-23R flagged as a possible biomarker of aging linked to senescence
A study in mice and human plasma identifies IL-23R as a protein that rises with age and is associated with cellular senescence.
- 12 days ago sciencedirect.com
Mitochondrial stress response proposed as a possible anti-aging target
A publication cites an article proposing the mitochondrial stress response as an approach against aging. The idea is still early-stage and does not report results from tests in people.
Single gene change extends fruit fly lifespan by up to 30%
A report describes an experiment with fruit flies in which changing a single gene extended the animals' lifespan by up to 30%. The finding comes from animals and does not show the same effect in people.
- 12 days ago newsweek.com
AP2A1 protein linked to reversing cellular aging
A Newsweek report says bioengineers have identified the AP2A1 protein, linked to reversing cellular aging, with possible relevance for age-related diseases.
- 12 days ago ashpublications.org
Clusterin proposed as a marker of aging in blood stem cells
Researchers from the University of Tokyo propose clusterin as a marker of aging-related changes in blood stem cells, which could help track this process over a lifetime.
- 12 days ago journals.plos.org
Doxifluridine extends worm lifespan through bacterial metabolism
A study in C. elegans worms found that doxifluridine reversed age-associated splicing defects and extended the animals' lifespan. The results are preliminary and have not been tested in people.
- 12 days ago academic.oup.com
Experts reach consensus on 14 candidate biomarkers of aging
An expert panel agreed, with at least 70%, on a list of 14 possible markers of biological aging, but did not present the list as definitive.
- 12 days ago
biorxiv.orgFirst chromosome-level genome of the Greenland shark
A preprint describes the first chromosome-level genome assembly of the Greenland shark, a long-lived deep-sea species, with 37,125 predicted genes. The study is a genomic analysis, not a trial in people.
- 12 days ago biorxiv.org
Fucoidan linked to longer lifespan in aged mice, preprint finds
A preprint not yet peer reviewed reports that fucoidan, a compound from brown algae, increased median lifespan in aged male mice and reduced frailty and epigenetic age in both sexes. These are animal results and do not show an effect in people.
- 12 days ago unilad.com
Hungarian worm study on slowing ageing: what can be concluded
A social media post, based on a UNILAD article, cites experiments with worms by a Hungarian university on ageing. The study is in animals and does not directly show what happens in people.
- 12 days ago science.org
Mitochondrial fatty acid oxidation linked to cellular senescence
A Science Advances article reports that DNA damage response signaling to mitochondria can trigger cellular senescence, with mitochondrial fatty acid oxidation driving the process.
- 12 days ago nature.com
Somatic mutations may drive aging more than epigenetic changes, study finds
A study published in Nature Aging reports that epigenetic clocks reflect age predictions based on the buildup of somatic mutations, and that mutations at CpG sites coincide with broad changes in the surrounding methylome.
- 12 days ago sciencedirect.com
Withaferin A, oxidative stress and sirtuins in cellular senescence
A study reports that withaferin A may regulate senescence and neuronal differentiation through oxidative stress and sirtuins. This is early research, not health guidance.
Young blood stem cells may ease aging signs in old mice
A study in mice reports that transplanting young hematopoietic stem cells into old mice eased aging-related traits and extended their lifespan. The evidence comes from animal research, not trials in humans.
- 12 days ago thebrighterside.news
Age-resistant stem cells reported to improve tissue health in monkeys
A news article reports that a study in monkeys found age-resistant human stem cells improved brain, bone and tissue health, with no side effects reported.
- 12 days ago nature.com
Cell Annealing model proposes resetting cells toward a youthful state
A modeling article in Cell Research describes the Cell Annealing model, which the author links to cells reset to a youthful state. It is a conceptual simulation, not an experiment.
- 12 days ago embopress.org
Chemical reprogramming eases aging markers and extends lifespan
A study published in EMBO Molecular Medicine reports that cocktails of small molecules reduced cellular aging markers and extended lifespan. It is early research, not a treatment.
- 12 days ago nature.com
Compound ZYZ-384 reduces aging markers in cell and animal studies
A preclinical study tested the compound ZYZ-384 in senescent endothelial cells and aged animal models, reporting reduced aging markers and inflammatory factors.
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