Aging
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Lab study reports reversing cellular age in human cells
A ScienceDaily report describes a lab study in which blood cells from an 80-year-old person were converted into neural stem cells with molecular age below 20, according to the article. The work was done in cells, not in people.
Blood cells from older donors reprogrammed into younger-like neural stem cells
Researchers in Bonn reprogrammed blood progenitor cells from an 80-year-old into neural stem cells that epigenetic clocks rated as much younger. This is an early study in cells, not in people.
Edible medicinal plant compounds and aging-related pathways: what the review reports
A review gathers animal and cell studies linking compounds from edible medicinal plants to pathways involved in aging, but it does not yet show effects in people.
New theory links mitochondrial energy flow to aging and disease
A theoretical proposal suggests that failures in how mitochondria use energy may contribute to aging and to diseases such as type 2 diabetes and Alzheimer's. The idea has not yet been tested.
SIRT1 overexpression protects mice from weight gain on high-fat diet
An animal study reported that raising the enzyme SIRT1 throughout the body protected mice from weight gain and heart mitochondrial problems, and improved part of glucose metabolism. The results come from animals and have not yet been tested in people.
NMN with a STING inhibitor preserved bone in aging mice
A study in middle-aged mice found that NMN combined with the STING inhibitor H-151 preserved bone density and structure, increased new bone formation and reduced inflammation. The results are preliminary and limited to animals.
SRSF1 gene: older cells with a younger profile in mice
A study in mice and human skin cells indicates that the SRSF1 gene made old cells look younger and that senescence fell in the human cells. The findings are preliminary.
Aged blood cells reprogrammed to appear decades younger
A news article reports that researchers made blood cells from an 80-year-old donor appear about 60 years younger. The findings are early and have not yet shown a health benefit for people.
- 12 days ago sciencedirect.com
Senescence may not fully explain aging of blood stem cells
A publication argues that changes seen in aged blood stem cells are not fully explained by senescence, the state in which cells stop dividing but remain in the body.
Study suggests menopause begins more than a decade before final period
An analysis of 300 million exams, led by Uri Alon and colleagues using a mathematical method from astronomy, indicates that menopause begins more than a decade before the last period.
- 12 days ago
pmc.ncbi.nlm.nih.govExercise and multidomain programs improve healthspan measures in trials
A systematic review of randomized clinical trials in people found that exercise and multidomain interventions were effective at improving healthspan measures, such as intrinsic capacity and quality of life.
- 12 days ago nature.com
Nature Aging article proposes a brain-body energy model of aging
A perspective article in Nature Aging proposes an energy-conservation model linking the brain and body. It connects brain responses to cytokine signals of hypermetabolism with cellular markers of aging. The idea has not yet been tested.
- 12 days ago link.springer.com
Mammal lifespan linked to SIRT6 phosphorylation sites
A comparative study across species links phosphorylation sites in the C-terminal domain of the SIRT6 protein to maximum lifespan in mammals, and points to a DNA repair protein as a possible factor in these differences.
- 12 days ago
biorxiv.orgPreprint maps muscle aging cells in 15 human donors
A preprint on bioRxiv, not yet peer reviewed, describes a single-cell atlas of muscle from 15 donors across adult life. The author claims that chronic inflammation plays a major role in human muscle aging.
- 12 days ago nature.com
SGLT2 inhibition clears senescent cells and eases aging traits in mice
A study in mice reports that SGLT2 inhibition reduced the burden of senescent cells and eased aging traits, through greater immune surveillance.
- 12 days ago biorxiv.org
Bat longevity and DNA virus-driven adaptation in Myotis species
A comparative genomic study of North American Myotis bats examines genes linked to long life and tolerance of infectious diseases. The work has not yet been peer reviewed.
BCG vaccine linked to reversing remyelination failure in aging
A publication citing a summary of a Cell Immunity study reports that the BCG vaccine may reverse the remyelination failure linked to aging. The finding is preliminary and still needs confirmation.
Citrate metabolism and inflammation in senescent cells
A Cell Reports article links citrate metabolism, through the enzyme ACLY, to inflammatory signals from senescent cells and suggests ACLY as a possible target for controlling the SASP. It is early research.
- 12 days ago biorxiv.org
Loss of H3K9 trimethylation linked to premature aging in a preprint
A bioRxiv preprint, not yet peer reviewed, reports that loss of H3K9 trimethylation leads to premature aging. Epigenetic changes are being studied as a possible driver of aging, relevant to research on healthy longevity.
- 12 days ago biorxiv.org
Machine learning predicts mouse lifespan-extending compounds (preprint)
A preprint on bioRxiv describes a computer model that tries to identify, from mouse lifespan data, which drugs could extend life. The study has not yet been peer reviewed.
- 12 days ago sciencedirect.com
New framework links epigenetic clocks to programmed aging mechanisms
Authors present an article proposing a conceptual framework to explain epigenetic clocks, including Horvath's, in terms of programmed aging mechanisms.
- 12 days ago science.org
Partial reprogramming gene therapy extends lifespan in mice
A study in mice from the Belmonte group reports about a 12% increase in lifespan with the Cdkn2a-OSK gene therapy, and about 38% more remaining life when it was started at 18 months of age.
Rate of DNA methylation change and maximum lifespan in mammals
A modeling study of 348 mammal species reported an inverse relationship between how fast DNA methylation changes and the maximum lifespan of each species.
- 12 days ago science.org
Reprogramming old cells extended mouse lifespan and aided wound healing
A study in mice reported that reprogramming old cells with the OSK factors improved wound healing and lifespan without causing cancer. Human trials are described as planned, not as results.
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