Aging · 5
Research on how we age, healthspan and what the evidence says about slowing it.
- AgingPost
Diabetes drug henagliflozin and telomere length in a clinical trial
A clinical trial linked the diabetes drug henagliflozin to longer telomeres. However, 66% of the placebo group also gained telomere length, which raises questions about how to interpret the result.
- AgingPost
Immune T cells that target senescent cells linked to longevity
A social media post claims that a type of helper T cell destroys senescent cells, which are seen in large numbers in supercentenarians. The post also says that removing these cells in mice accelerated aging. The claims are not yet confirmed.
- AgingPost
Jewel wasp diapause extends lifespan and slows the epigenetic clock
A study of jewel wasps, invertebrates used as research animals, linked diapause, a pause in development, to a longer adult lifespan and a slower epigenetic clock.
- AgingPost
Model Links Somatic Mutations to Lifespan Limits in Organs
A computational modelling study suggests somatic mutations may lower the theoretical human lifespan limit, with neurons and heart cells acting as bottlenecks. It is a theoretical projection, not a trial in people.
- AgingPost
Naked mole-rat cGAS variant may support DNA repair
A social media post describes a study linking four amino acid changes in the naked mole-rat's cGAS protein to DNA repair that differs from the human version.
- AgingPost
Newborn blood metabolites differ from adult blood, study finds
A study in Aging Cell compared metabolites in umbilical cord blood with adult blood. In C. elegans worms, a mix of five metabolites extended their lifespan and healthspan.
- AgingPost
Six Genes Linked to Aging Identified in Worm Study
A study published in the journal Aging Cell analyzed 25 gene expression datasets and tested the results in C. elegans worms. The researchers identified 6 genes whose suppression extended the worms' lifespan by up to 15%.
- AgingPost
Stressed cells may switch on a repair program, animal studies suggest
An article summarizes studies in which cells exposed to a stress compound first activated growth and repair genes, then energy and rebuilding systems. The cited work was done in mice, flies, frogs and worms.
- AgingPost
Yeast study links TOR pathway and agmatinase enzymes to aging
A study in yeast reported that the drug rapalink-1, which acts on the TOR growth pathway, prolonged life, and that agmatinase enzymes help regulate that pathway.
- AgingPost
Blocking one protein clears old cells and reduces fibrosis in mice
A study in cells and aged mice reports that a small molecule disrupting the PGAM1–Chk1 interaction eliminated senescent cells, with little effect on healthy cells. Treated animals had less pulmonary fibrosis and lower inflammatory markers.
- AgingPost
Clearing senescent cells restored gut regeneration in aging mice
A study in mice reported that CAR T cells targeting uPAR removed senescent cells from the aging gut and increased stem cell activity. Early tests with human cells showed similar responses.
- AgingPost
Four gene regulators reset aged cells in UCSF cell and mouse study
A UCSF study with human cells and aged mice reports that four transcription factors can restore younger gene patterns. The findings come from cells and animals, not yet from people.
- AgingPost
Liver cells reprogrammed to boost T-cell output in aged mice
An animal study described by an article reports that liver cells, reprogrammed with mRNA, began acting like the thymus and restored T-cell production in aged mice.
- AgingPost
Mouse study links mitochondrial organization to longer lifespan
In genetically modified mice with more COX7RP, males lived about 6.6% longer, with no significant gain in females. This is an animal finding that does not automatically apply to people.
- AgingPost
Mouse study links Polycomb chromatin changes to epigenetic aging
A study of mouse skin cells reported more disordered epigenetic patterns with age, concentrated in regions regulated by PRC2. Partial reprogramming with OSKM factors reversed many of these changes.
- AgingPost
Nature review proposes loss of epigenetic control as a cause of ageing
A review published in Nature describes ageing as a whole-system failure of epigenetic control, with four interlinked failure modes. It is a proposed mechanism, not a test in people.
- AgingPost
Opinion: aging as an epigenetic program and changes in bursts
An opinion thread argues that aging is a programmed, epigenetic process in which biological age changes in bursts. It cites a 2024 Stanford study on state transitions.
- AgingPost
Protein linked to neural stem cell renewal in aging brains
An article reports that researchers reportedly identified a protein that may help aging brains maintain the renewal of neural stem cells, a process linked to memory and learning.
- AgingPost
Protein ReHMGB1 linked to spreading aging signals in mice
A mouse study from Korea University, published in the journal Metabolism, suggests that the protein ReHMGB1, released by senescent cells, may cause aging-like effects in distant tissues. Blocking the protein with antibodies was associated with fewer aging signs.
- AgingPost
Retro Biosciences begins Phase 1 trial of aging drug candidate RTR242
The article reports that Retro Biosciences has started a Phase 1 trial of RTR242, a small molecule linked to cellular cleanup. The trial is randomized, placebo-controlled and enrolls healthy volunteers.
- AgingPost
SIRT6 Enzyme Linked to Tryptophan Shifts in Aging Brains
A report describes how SIRT6 levels fall as the brain ages, shifting tryptophan toward the kynurenine pathway. The findings come from animal studies and are preliminary.
- AgingPost
Article claims diabetes drug henagliflozin lengthened telomeres in a trial
An article reports a 26-week trial of henagliflozin in which more treated people had longer telomeres than those on placebo. The result is preliminary and needs independent verification.
- AgingPost
Blood proteins may reveal uneven aging across cell types
An article reports that blood proteins from more than 60,000 people may help measure aging in specific cell types, which could be relevant to understanding disease risk.
- AgingPost
Cyb5b protein and gene switching by electromagnetic fields in a mouse study
A study from a Seoul group, reported in the journal Cell, describes the Cyb5b protein as a possible switch for genes under electromagnetic fields. The results are preliminary and come from animals, not people.
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