Aging · 7
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Aging as a continuation of developmental programs: a hypothesis
A social media post presents a hypothesis by researcher João Pedro de Magalhães that aging may be developmental programs that become harmful after reproductive maturity.
- 12 days ago nature.com
Citrulline and age-related fat buildup in C. elegans worms
In a study of the C. elegans worm, more citrulline was linked to more age-related lipid buildup and a shorter lifespan. This is animal research, not yet shown to apply to people.
Engineered enzyme reduced AGE damage in human tissue samples
A proof-of-concept study reported that an engineered enzyme removed advanced glycation end products from human tissue samples in the lab, lowering the damage to levels similar to those of a much younger person.
- 12 days ago nature.com
Enzyme reverses protein aging marker in lab and tissue samples
A study in Nature Communications describes an enzyme that can reverse an aging-linked protein damage marker in laboratory experiments and in human tissue samples. The results are preliminary.
- 12 days ago link.springer.com
Epigenetic aging clocks and biological aging in men with cardiometabolic disturbances
A study of men with cardiometabolic disturbances compared different epigenetic aging clocks. Some, including GrimAge and DunedinPACE, detected accelerated biological aging, while first-generation clocks largely did not.
- 12 days ago onlinelibrary.wiley.com
Lacking LET-607 extends lifespan in animal study
A study in C. elegans worms reports that worms without the LET-607 protein lived longer, through a process linked to the cell's stress response. The results come from animals and have not been tested directly in people.
- 12 days ago
pmc.ncbi.nlm.nih.govLongevity Aesthetics: A New Conceptual Framework for Aesthetic Medicine
A conceptual article proposes that aesthetic medicine move beyond correcting visible signs of aging and adopt a longevity model based on geroscience, which has not yet been tested in practice.
Mouse study suggests TBMS1 compound removes senescent cells
A Tsinghua University team reported, in mice, that the TBMS1 compound removes senescent cells by acting on the ATP1A1 protein, improving several age-related conditions.
- 12 days ago nature.com
Thymus research aims to slow immune aging
A Nature news article reports that scientists are trying to regenerate the thymus, an immune organ that shrinks with age, in hope of slowing the aging of the body's immune defenses.
- 12 days ago link.springer.com
Wild blueberry metabolites linked to slower telomere shortening in cells
A laboratory study in cells found that metabolites of wild blueberry polyphenols slowed telomere shortening in an in vitro model of metabolic syndrome. The result has not been tested in people.
- 12 days ago lifespan.io
Activating the GPR40 receptor slows thymus aging in mice
A study published in Aging Cell reports that activating the GPR40 receptor in thymic epithelial cells slowed thymic involution, the age-related shrinking of the thymus, in mice.
- 12 days ago
biorxiv.orgChemotherapy lowers muscle NAD+ in mice, preprint finds
A preprint in healthy mice reported that common chemotherapy regimens reduced NAD+ in skeletal muscle and, after prolonged treatment, also in the liver. The loss of muscle NAD+ accompanied muscle atrophy. The study has not yet been peer reviewed.
- 12 days ago minervamedica.it
Critical review examines myths and limits of popular longevity recipes
A review published in Minerva Medica examines popular claims about living longer and the limits of the available evidence behind each one.
Engineered enzyme reduces AGE damage in human tissue samples
A proof-of-concept study reports that an engineered enzyme removed AGEs, advanced glycation end products, from human tissue samples, including tissue from a 75-year-old donor.
- 12 days ago lifespan.io
Engineered enzyme removes advanced glycation end products from proteins
Scientists engineered an enzyme that removes an advanced glycation end product from proteins, a change previously considered very difficult to reverse. The work is described as early-stage.
- 12 days ago nature.com
Enzyme reverses protein chemical aging in lab and tissue samples
A Nature Communications study describes the enzyme CMLase, which acts on a glycation marker and restores proteins in laboratory tests and in human tissue samples.
- 12 days ago pubmed.ncbi.nlm.nih.gov
Fucoxanthin extends lifespan in roundworm study
A study on the roundworm C. elegans found that fucoxanthin, a compound from algae, extended the average lifespan of the animals by 12.1% and slowed the loss of movement. The results come only from laboratory animals.
Glutamate reduces aging skin cells in pre-clinical study
A report describes glutamate reducing senescent cells in experiments with skin cells. The author describes the work as entirely pre-clinical, meaning it is far from being tested in people.
- 12 days ago newsweek.com
Mathematical model suggests humans could theoretically reach 156 years
A new modelling study suggests a theoretical human lifespan limit of 156 years. It is a model, not a trial in people, and not a prediction about real individuals.
Mouse study links senescent brain immune cells to brain aging
In aged mice, senescent immune cells built up in the brain's white matter. According to the report, targeting these cells reduced cells linked to inflammation. The finding comes from animals and does not yet tell us about people.
Nervous system imbalance as a possible starting driver of aging
A perspective published in the journal npj Aging proposes that chronic sympathetic dominance and lower parasympathetic tone may drive markers of aging. It is a theoretical hypothesis still under discussion.
- 12 days ago aging-us.com
Paper proposes testing Hydra genes in rotifers to extend lifespan
An article in the journal Aging hypothesizes that introducing gene expression profiles similar to those of Hydra into rotifers could extend healthspan and reduce age-related mortality. It is a research proposal, not a tested result.
- 12 days ago nature.com
Blocking R-loop export from aging cells reduces inflammation, study finds
A study in Nature Aging, based on cells and animals, reports that blocking XPO1 reduced R-loop export and aging-related inflammation.
Blocking the EP2 receptor restores immune cleanup in aged mice
A Stanford study in aged mice suggests that tissue macrophages lose the ability to clear senescent neutrophils with age, and that blocking the EP2 receptor restored this cleanup, reducing inflammation and preserving organs.
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