Blocking an enzyme in old mice extended lifespan in a study
A study in mice found that blocking the enzyme legumain starting in old age improved NAD+ markers, frailty, and some physical and memory tests. The results are early and come from animals.
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What the research shows
In a study of mice, researchers blocked the enzyme legumain starting in the animals' old age. According to the study, the intervention improved markers linked to NAD+, frailty, and some physical and memory tests, and the average lifespan of treated animals was about 10 months. Some treated animals ate a little less, and the authors call for a dedicated feeding study to understand this point.
This kind of research is done in animals and helps test ideas before any study in people. Because the intervention started late, in old age, the result is more relevant to aging, but it is still early evidence. The authors themselves note that these findings do not show the same effects in humans.
What it means
The study suggests that legumain may be a target of interest for research on aging and frailty. It is still unknown whether the same blockade would work in people, safely and with similar benefits. Researchers also still need to understand the role of feeding in the results.
How to read it with care
A result in mice does not replace a medical consultation and should not lead to changes in diet, supplements, or treatments. Anyone considering a change should talk to a doctor or another qualified health professional.