Aging · 3
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- 12 days ago lighthouse.mq.edu.au
Human protein found to help repair damaged DNA, study says
Researchers at Macquarie University report that a protein naturally present in human cells takes part in repairing damaged DNA, with possible relevance to age-related diseases.
- 12 days ago zenodo.org
Poster proposes that somatic mutations and cancer risk may help drive aging
A theoretical poster presented at a German aging congress proposes that cancer risk has been a dominant force in the evolution of aging.
- 12 days ago
biorxiv.orgPreprint links SRSF1 gene to possible cellular rejuvenation
A preprint not yet peer reviewed reports that a transcriptomic screen identified SRSF1 as a possible cellular rejuvenation factor, within a line of research seeking alternatives to reprogramming methods.
- 12 days ago nature.com
Psilocybin linked to longer cell lifespan and survival in aged mice
A study in npj Aging reports that psilocybin extended the lifespan of cells and improved survival in aged mice. The findings come from experiments with cells and animals, not people.
- 12 days ago researchsquare.com
Seaweed fucoidan linked to fewer senescent cells in mice, preprint study finds
A preprint study in mice reports that a seaweed sugar compound, fucoidan-FV, reduced senescent cells and improved DNA repair. The author claims it improved the animals' health. This is early animal research, not human evidence.
- 12 days ago biorxiv.org
Single gene lowers epigenetic age in cultured skin cells, preprint finds
A preprint on bioRxiv, not yet peer reviewed, reports that boosting the activity of one gene lowered estimated epigenetic age in cultured fibroblasts and keratinocytes grown in the laboratory.
- 12 days ago biorxiv.org
Sulforaphane extends lifespan in C. elegans worms in preliminary study
A preprint not yet peer reviewed reports that sulforaphane, a compound found in cruciferous vegetables, extended the lifespan of C. elegans worms by more than 50% at the most effective doses when started early in life.
- 12 days ago scitechdaily.com
Declining menin in hypothalamus linked to aging in mice
A study in mice reports that falling menin levels in the hypothalamus trigger inflammation and speed up aging. Raising menin or giving D-serine restored memory, learning and physical vitality in older mice.
Inhibiting CD38 raises NAD+ in macrophages from old mice
In cells from old mice, blocking the enzyme CD38 with compound 78c raised NAD+ levels and reduced inflammation and oxidative stress caused by oral pathogens. These are laboratory results, not findings in people.
NAD+ precursors in human aging: what the clinical evidence shows
One review summarizes clinical trials of NAD+ precursors in people and the questions that remain open. A second review covers the role of NAD+ in bacterial immunity.
- 12 days ago science.org
Naked mole rat cGAS mutations may help explain its long lifespan
A publication citing an article in Science reports four mutations in a naked mole rat enzyme, linked to more efficient DNA repair and less inflammation.
- 12 days ago scitechdaily.com
New treatment reported to extend lifespan in elderly male mice
A SciTechDaily article reports that a new treatment extended lifespan by more than 70% in elderly male mice, in an animal study.
Roadmap lists 100 open problems in ageing science
A review gathers 100 unresolved questions about ageing and longevity, compiled with the research community and analyzed with natural language processing to find gaps in research.
Small molecule AA-20 boosts autophagy and extends worm lifespan
A study in C. elegans worms reports that the small molecule AA-20 increases autophagy, the cell's internal cleanup process, removes buildups of lipids and proteins, and extends the animals' lifespan, without inhibiting mTORC1. The results come from animals and do not show effects in humans.
- 12 days ago biorxiv.org
Suppressing a stress-response pathway extended fly lifespan in preprint
A preprint study in fruit flies reported that suppressing the GCN2-ATF4 stress-response pathway, rather than activating it, extended lifespan. The work has not yet been peer reviewed.
- 12 days ago nature.com
Ubiquitin activates SPRTN protease to repair DNA-protein crosslinks
The article in Nature Communications reports that binding to ubiquitin activates the SPRTN protease, an enzyme that cuts toxic DNA-protein links and supports genome stability during DNA repair.
- 12 days ago biorxiv.org
CD4+ T cells release telomere rivers in a preliminary study on rejuvenation
A preprint on bioRxiv, not yet peer reviewed, describes CD4+ T cells releasing telomere-containing vesicles, called 'rivers', and links their formation to fatty acid oxidation.
- 12 days ago lifespan.io
Cord blood metabolites linked to slower aging in worms
A study compared human umbilical cord blood with adult plasma and identified metabolites with anti-senescence properties. The findings come from experiments in cells and worms.
- 12 days ago nature.com
Engineered stem cells and aging in monkeys: a 2025 Cell study
A monkey study published in the journal Cell in 2025 tested engineered stem cells against signs of aging. The results come from animals and do not directly apply to people.
- 12 days ago medrxiv.org
Genetic study links proteomic aging clock to longevity and disease
A preprint on medRxiv with 38,865 UK Biobank participants identified 27 genetic loci linked to proteomic age gap, a biological measure of aging, and a strong genetic correlation with longevity.
- 12 days ago medrxiv.org
GrimAge clock predicts survival in cognitively healthy centenarians
A preliminary study, published as a preprint, followed 247 cognitively healthy Dutch centenarians and found that faster epigenetic aging measured by the GrimAge clock was linked to a higher risk of death.
- 12 days ago biorxiv.org
IF1 protein and aging: preprint in mice and across species
A preprint not yet peer reviewed reports that the IF1 protein inhibits ATP hydrolysis and that higher IF1 correlates with greater maximum lifespan across species.
- 12 days ago biorxiv.org
Kidney cell atlas links epithelial cells to epigenetic aging
An unreviewed preprint describes a single-cell multi-omic atlas of healthy and injured human kidneys, along with aged mouse kidneys. The authors report accelerated epigenetic aging, with tubular epithelial cells predominating in diseased kidneys.
Mesenchymal cells may help rebuild the aging thymus
An article in Nature Biotechnology reports that a group of mesenchymal cells was able to restore thymus function in mice and in human tissue. The thymus is an organ tied to the body's defenses that shrinks with age. The findings are preliminary and come from animal studies and human tissue samples.
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