Single gene lowers epigenetic age in cultured skin cells, preprint finds
A preprint on bioRxiv, not yet peer reviewed, reports that boosting the activity of one gene lowered estimated epigenetic age in cultured fibroblasts and keratinocytes grown in the laboratory.
Source: Single gene lowers epigenetic age in cultured skin cells: preprint (biorxiv.org). Summary written with AI from the source and reviewed by rules; read the original.
What the research shows
The preprint, posted on bioRxiv, tested whether overexpressing a single gene, meaning forcing it to be more active than usual, could change estimates of epigenetic age. These estimates are markers calculated from chemical patterns on DNA. According to the study, in the cells analysed, cultured fibroblasts and keratinocytes grown in the laboratory, the estimated epigenetic age decreased.
Because this is a preprint, the work has not yet gone through peer review, the stage where other experts assess methods and conclusions before journal publication. It is also a study in cells: it does not show what would happen in people, in living tissues or in health. Epigenetic markers are researched as indicators of ageing, but a change in a marker inside a laboratory dish does not mean ageing more slowly or living longer.
What it means
The result suggests that a single factor can change markers of cell age in culture. It is still unknown whether this effect occurs in living organisms, whether it is safe, or whether it would bring any benefit to human health.
How to read it with care
This result does not replace a consultation. Anyone considering a change in diet, supplements or treatment should talk to a doctor or another qualified health professional.