Aging
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Blood cells from older donors reprogrammed into younger-like neural stem cells
Researchers in Bonn reprogrammed blood progenitor cells from an 80-year-old into neural stem cells that epigenetic clocks rated as much younger. This is an early study in cells, not in people.
SIRT1 overexpression protects mice from weight gain on high-fat diet
An animal study reported that raising the enzyme SIRT1 throughout the body protected mice from weight gain and heart mitochondrial problems, and improved part of glucose metabolism. The results come from animals and have not yet been tested in people.
NMN with a STING inhibitor preserved bone in aging mice
A study in middle-aged mice found that NMN combined with the STING inhibitor H-151 preserved bone density and structure, increased new bone formation and reduced inflammation. The results are preliminary and limited to animals.
SRSF1 gene: older cells with a younger profile in mice
A study in mice and human skin cells indicates that the SRSF1 gene made old cells look younger and that senescence fell in the human cells. The findings are preliminary.
Study suggests menopause begins more than a decade before final period
An analysis of 300 million exams, led by Uri Alon and colleagues using a mathematical method from astronomy, indicates that menopause begins more than a decade before the last period.
Rate of DNA methylation change and maximum lifespan in mammals
A modeling study of 348 mammal species reported an inverse relationship between how fast DNA methylation changes and the maximum lifespan of each species.
Roadmap lists 100 open problems in ageing science
A review gathers 100 unresolved questions about ageing and longevity, compiled with the research community and analyzed with natural language processing to find gaps in research.
Mesenchymal cells may help rebuild the aging thymus
An article in Nature Biotechnology reports that a group of mesenchymal cells was able to restore thymus function in mice and in human tissue. The thymus is an organ tied to the body's defenses that shrinks with age. The findings are preliminary and come from animal studies and human tissue samples.
Anti-IL-11 antibodies in mice and a report of longer lifespan
A social media report describes mice treated with anti-IL-11 antibodies living 20% to 25% longer. The source is an animal study, with no indication of the same effect in people.
Canagliflozin, senescent cells and aging in mice: what the study suggests
A study in mice published in Nature Aging links the effect of canagliflozin, a diabetes medicine, to the removal of senescent cells. The findings are early, come from animals, and do not show anything about people.
AMPK-linked protein tied to metabolism and lifespan in worms
A study in worms reports that AMPK activates the protein NUP50, which also affects metabolism, and that higher levels of it were associated with longer lifespan in these animals.
Clearing senescent cells in aged mice extended lifespan in one study
One study in mice reports that monthly clearing of senescent cells reduced inflammation, improved physical and metabolic health and extended lifespan, especially in females. The results are early and come from animals.
Mice study: gene reprogramming partly reversed eye aging
A Harvard study in mice reports that three genes used to reprogram eye cells helped attenuate eye aging and restore vision. The result comes from animals and is still preliminary.
Partial reprogramming and the idea of epigenetic rejuvenation
An opinion-toned article explains partial reprogramming with Yamanaka factors, a research line proposing cellular rejuvenation. The approach is still under testing and is not a proven way to slow aging.
Preprint: FAM162A overexpression linked to longer fruit fly lifespan
A preprint reports that fruit flies overexpressing the mitochondrial protein FAM162A lived about 25% longer, in an animal study not yet peer reviewed.
Preprint links DNA methylation change rates to aging drift
A preprint reports patterns in how quickly DNA methylation changes at specific sites, changes the article says build up over time as aging drift. The work is preliminary and has not yet been peer reviewed.
Smaller nucleolus linked to slower aging in yeast study
A study in yeast cells reported that keeping the nucleolus small appeared to slow aging, to a degree similar to calorie restriction. The results come from yeast, not people.
Very long-lived people may offset markers of aging
A preprint analyzed the biological profile of a 118-year-old person and found that shortened telomeres and mutated blood stem cells did not necessarily predict poor health.
Young blood stem cells and the lifespan of old mice
A study in mice reports that transplanting young blood stem cells into old animals may ease signs of aging and extend lifespan. This is early animal research with no direct application to people yet.
AI identifies senescent cells by the shape of their nuclei
An article reports an artificial intelligence tool, developed by researchers at NYU, that identifies and tracks senescent cells based on changes in their nuclei. The article does not present clinical results.
Early NewLimit data report partial restoration of youthful liver cell function
A founder of the company NewLimit reports preliminary experiments in which the prototype drug M0004, tested in disease models, partly restored function in aged liver cells. The results have not been peer reviewed.
Fisetin clears senescent cells and prevents aortic aging in mice
In a study of diabetic mice, fisetin, a polyphenol found in strawberries, cleared senescent cells and prevented aging of the aorta.
Mouse lifespan study of damage-repair treatments ends with a qualified result
A post by Aubrey de Grey of the LEV Foundation shares final survival curves from a mouse study of damage-repair treatments. The results are preliminary and come from animals.
New conceptual 'Cell Annealing' model proposed to explain cellular aging
Researchers presented a conceptual model called Cell Annealing, which describes cell states as points on a high-dimensional landscape traveled during aging and reprogramming. It is a theoretical proposal that has not yet been tested.
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