Aging · 6
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Opinion: aging as an epigenetic program and changes in bursts
An opinion thread argues that aging is a programmed, epigenetic process in which biological age changes in bursts. It cites a 2024 Stanford study on state transitions.
Protein linked to neural stem cell renewal in aging brains
An article reports that researchers reportedly identified a protein that may help aging brains maintain the renewal of neural stem cells, a process linked to memory and learning.
Protein ReHMGB1 linked to spreading aging signals in mice
A mouse study from Korea University, published in the journal Metabolism, suggests that the protein ReHMGB1, released by senescent cells, may cause aging-like effects in distant tissues. Blocking the protein with antibodies was associated with fewer aging signs.
Retro Biosciences begins Phase 1 trial of aging drug candidate RTR242
The article reports that Retro Biosciences has started a Phase 1 trial of RTR242, a small molecule linked to cellular cleanup. The trial is randomized, placebo-controlled and enrolls healthy volunteers.
SIRT6 Enzyme Linked to Tryptophan Shifts in Aging Brains
A report describes how SIRT6 levels fall as the brain ages, shifting tryptophan toward the kynurenine pathway. The findings come from animal studies and are preliminary.
Article claims diabetes drug henagliflozin lengthened telomeres in a trial
An article reports a 26-week trial of henagliflozin in which more treated people had longer telomeres than those on placebo. The result is preliminary and needs independent verification.
Blood proteins may reveal uneven aging across cell types
An article reports that blood proteins from more than 60,000 people may help measure aging in specific cell types, which could be relevant to understanding disease risk.
Cyb5b protein and gene switching by electromagnetic fields in a mouse study
A study from a Seoul group, reported in the journal Cell, describes the Cyb5b protein as a possible switch for genes under electromagnetic fields. The results are preliminary and come from animals, not people.
Gene in worms and lifespan: what a social media post reports
A social media post describes experiments with worms in which switching off one gene reportedly doubled lifespan, including in older worms. The result has not yet been checked against a peer-reviewed publication.
Human partial reprogramming eye study for glaucoma and NAION completes enrollment
A first-in-human study testing partial cellular reprogramming in the eye has completed enrollment. Safety data are expected in Q4 2026, and no efficacy results have been released yet.
Information loss theory of aging: an unproven hypothesis from a 2008 lab
An article presents the claim that aging may stem from loss of epigenetic information after DNA breaks, citing 2008 work from a Sinclair lab. It is a debated hypothesis, not a proven result.
Partial cell reprogramming and aging in mice
A social media post describes studies in mice in which partial cell reprogramming made old animals younger and, according to the text, about 30% longer-lived. The results come from animal research.
Senolytic and NAD-boosting combination extended mouse lifespan by 33%
In mice, an oral combination of quercetin, NR, urolithin A and alpha-lipoic acid, started at 18 months of age, increased median remaining survival by 33%. The results are early and do not show an effect in people.
SGLT2 inhibitor linked to longer telomeres in diabetes trial
A randomized, double-blind trial of 150 adults with type 2 diabetes linked henagliflozina, an SGLT2 inhibitor, to longer telomeres after 26 weeks, compared with placebo.
Three-Year Study Reports Brain Health Gains at Advanced Ages
A three-year study of nearly 4,000 adults reported improved brain health at any age, including people in their 80s and 90s. The researchers say the results challenge the idea that cognitive decline is inevitable.
An Opinion Piece Argues Aging Mixes Random Damage and Regulated Processes
An opinion article, citing an unnamed review, proposes that aging combines accumulated errors whose rate is shaped by evolved regulatory networks, rather than being either purely random damage or programmed death.
Ant study links a peptide to caste switch and longer lifespan
A study in Harpegnathos ants reports that the peptide HCRG1 suppresses juvenile hormone and coordinates changes in reproduction and lifespan in these insects.
- 12 days ago nature.com
DNA methylation aging differs across 17 human tissues
A computational meta-analysis of nearly 16,000 human DNA methylation profiles found aging marks shared across tissues, but also many changes specific to each organ.
Early trial of AMPK activator ATX-304 reports metabolic changes
An early phase 1b trial in people with obesity or prediabetes reported improvements in liver fat, visceral fat and resting metabolic rate after 8 weeks of taking the compound ATX-304.
- 12 days ago journals.plos.org
Long-term low-dose rapamycin and aging-linked immune cells
A study published in PLOS ONE reports that long-term exposure to low-dose rapamycin limited the expansion of age-linked gamma delta T cells and neuroinflammation, with small overall immune changes. The findings are preliminary.
- 12 days ago rapamycin.news
Partly overlapping metabolic patterns across five aging-related interventions
A study in mice compared five aging-related interventions across seven tissues. Metabolic patterns partly overlapped, and a machine learning model could identify the treated mice.
Review examines biological clocks that track aging through blood proteins
A review by Eric Topol and a coauthor examines so-called biological clocks, which estimate the pace of aging from blood proteins, and links them to functional health, longevity and disease.
Social media post claims aging shifts at ages 33, 60, 69 and 78
A social media post says a Nature Medicine article found 'aging waves' across 7 studies, around ages 33, 60, 69 and 78. This piece explains the idea and the questions it still leaves open.
- 12 days ago youtube.com
Talk reports thymus regrowth in older adults in TRIIM studies
A talk by Dr. Greg Fahy presents early data from the TRIIM and TRIIM-X studies, which, according to the video description, regenerated the thymus in older people.
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